Synthesis of skeletally diverse β-lactam haptens for the in vitro diagnosis of IgE-mediated drug allergy.
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DOI: 10.1039/d2cc01677j
Abstract: We present the first synthesis of β-lactam-derived haptens, leveraging the principles of diversity-oriented synthesis to discover compounds for drug allergy in vitro testing. We designed, synthesised, and performed in vitro immunological evaluation on 18 structurally… read more here.
Keywords: synthesis skeletally; lactam; drug allergy; synthesis ... See more keywords