Elucidation of the tyrosinase/O2/monophenol ternary intermediate that dictates the monooxygenation mechanism in melanin biosynthesis
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DOI: 10.1073/pnas.2205619119
Abstract: Significance Melanins are ubiquitous photoprotective biopolymer pigments with major implications ranging from fruit browning to severe human diseases, including skin cancer. Tyrosinase, the enzyme catalyzing the rate-limiting step in melanin biosynthesis is thus an important… read more here.
Keywords: ternary intermediate; tyrosinase; melanin biosynthesis; mechanism ... See more keywords