Articles with "tetrazole peptidomimetics" as a keyword



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Discovery of potent and selective inhibitors of the Escherichia coli M1-aminopeptidase via multicomponent solid-phase synthesis of tetrazole-peptidomimetics.

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Published in 2019 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2018.11.074

Abstract: The Escherichia coli neutral M1-aminopeptidase (ePepN) is a novel target identified for the development of antimicrobials. Here we describe a solid-phase multicomponent approach which enabled the discovery of potent ePepN inhibitors. The on-resin protocol, developed… read more here.

Keywords: potent selective; discovery potent; escherichia coli; aminopeptidase ... See more keywords