Synthesis and antimalarial activity of 3′-trifluoromethylated 1,2,4-trioxolanes and 1,2,4,5-tetraoxane based on deoxycholic acid
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DOI: 10.1016/j.steroids.2017.11.008
Abstract: HIGHLIGHTSDeoxycholic acid ozonides were synthesized via the Griesbaum coozonolysis for the first time.Two novel steroidal tetraoxanes were obtained by acid‐catalyzed peroxycondensation.Antimalarial activity was evaluated and potency for related compounds was compared. ABSTRACT A series of… read more here.
Keywords: methyl; deoxycholic acid; antimalarial activity; trifluoromethylated trioxolanes ... See more keywords