Cerebrospinal Fluid Biomarkers in Patients With Unipolar Depression Compared With Healthy Control Individuals: A Systematic Review and Meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2022.0645
Abstract: Importance Depression has been associated with alterations in neurotransmitters, hormones, and inflammatory and neurodegenerative biomarkers, and biomarkers quantified in the cerebrospinal fluid (CSF) are more likely to reflect ongoing biochemical changes within the brain. However,… read more here.
Keywords: healthy control; studies smd; unipolar depression; control individuals ... See more keywords
Cannabis Use Disorder and Subsequent Risk of Psychotic and Nonpsychotic Unipolar Depression and Bipolar Disorder.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2023.1256
Abstract: Importance Cannabis use is increasing worldwide and is suspected to be associated with increased risk of psychiatric disorders; however, the association with affective disorders has been insufficiently studied. Objective To examine whether cannabis use disorder… read more here.
Keywords: cannabis use; bipolar disorder; use; unipolar depression ... See more keywords
Anger and cluster B personality traits and the conversion from unipolar depression to bipolar disorder
Sign Up to like & getrecommendations! Published in 2021 at "Depression and Anxiety"
DOI: 10.1002/da.23137
Abstract: Feelings of anger and irritability are prominent symptoms of bipolar disorder (BD) that may occur during hypomanic, depressive and, especially, during mixed mood states. We aimed to determine whether such constructs are associated with the… read more here.
Keywords: depression; anger cluster; conversion; bipolar disorder ... See more keywords
Sample heterogeneity in unipolar depression as assessed by functional connectivity analyses is dominated by general disease effects.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2017.06.055
Abstract: OBJECTIVES Combinations of resting-state fMRI and machine-learning techniques are increasingly employed to develop diagnostic models for mental disorders. However, little is known about the neurobiological heterogeneity of depression and diagnostic machine learning has mainly been… read more here.
Keywords: depression; general disease; heterogeneity; unipolar depression ... See more keywords
Alterations in CRY2 and PER3 gene expression associated with thalamic-limbic community structural abnormalities in patients with bipolar depression or unipolar depression.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2021.10.125
Abstract: OBJECTIVES The current study aimed to identify shared and distinct brain structure abnormalities and their relationships with the expression of circadian genes in patients with bipolar or unipolar depression. METHOD A total of 93 subjects… read more here.
Keywords: depression; compared controls; bipolar depression; patients bipolar ... See more keywords
Differentiating between bipolar and unipolar depression in functional and structural MRI studies
Sign Up to like & getrecommendations! Published in 2019 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2018.03.022
Abstract: &NA; Distinguishing depression in bipolar disorder (BD) from unipolar depression (UD) solely based on clinical clues is difficult, which has led to the exploration of promising neural markers in neuroimaging measures for discriminating between BD… read more here.
Keywords: depression; functional structural; structural mri; mri studies ... See more keywords
The prevalence and outcomes of exposure to potentially traumatic stressful life events compared across patients with bipolar disorder and unipolar depression
Sign Up to like & getrecommendations! Published in 2017 at "Psychiatry Research"
DOI: 10.1016/j.psychres.2017.06.070
Abstract: This study examined the profile of stressful life experiences in patients with unipolar depression (UP) compared to bipolar disorder (BP), including their subsequent psychological impact and affirmation of post-traumatic stress symptoms. We studied 747 tertiary… read more here.
Keywords: group; bipolar disorder; unipolar depression; life ... See more keywords
Staging of unipolar depression: systematic review and discussion of clinical implications
Sign Up to like & getrecommendations! Published in 2022 at "Psychological Medicine"
DOI: 10.1017/s0033291722001507
Abstract: Abstract Staging has been increasingly used in unipolar depression since its introduction in the nineties. Several models are available, but their differential features and implications are not completely clear. We systematically reviewed: (a) staging models… read more here.
Keywords: staging models; depression; depression systematic; treatment ... See more keywords
Evidence-based pharmacotherapy of treatment-resistant unipolar depression
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Psychiatry in Clinical Practice"
DOI: 10.1080/13651501.2016.1248852
Abstract: Abstract Treatment resistance to the antidepressive pharmacotherapy represents one of the most important clinical challenges in the pharmacological management of unipolar depression. In this review, we aimed to summarise the evidence for various pharmacological treatment… read more here.
Keywords: treatment; resistant unipolar; evidence; unipolar depression ... See more keywords
Divergent and Convergent Imaging Markers Between Bipolar and Unipolar Depression Based on Machine Learning
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Journal of Biomedical and Health Informatics"
DOI: 10.1109/jbhi.2022.3166826
Abstract: Distinguishing bipolar depression (BD) from unipolar depression (UD) based on symptoms only is challenging. Brain functional connectivity (FC), especially dynamic FC, has emerged as a promising approach to identify possible imaging markers for differentiating BD… read more here.
Keywords: based machine; depression; machine learning; imaging markers ... See more keywords
Patterns and predictors of conversion to bipolar disorder in 91 587 individuals diagnosed with unipolar depression
Sign Up to like & getrecommendations! Published in 2018 at "Acta Psychiatrica Scandinavica"
DOI: 10.1111/acps.12869
Abstract: Conversion from unipolar depression (UD) to bipolar disorder (BD) is a clinically important event that should lead to treatment modifications. Unfortunately, recognition of this transition is often delayed. Therefore, the objective of this study was… read more here.
Keywords: unipolar depression; predictors conversion; bipolar disorder; patterns predictors ... See more keywords