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Highlights • K155M stabilizes V1V2 β-strand conformation relevant to broad antibody recognition.• β-strand stabilized V1V2 immunogens elicit antibody responses with greater cross-reactivity.• Fine-tuning immunogen conformation modulates immunogenicity. Click to show full abstract
Highlights • K155M stabilizes V1V2 β-strand conformation relevant to broad antibody recognition.• β-strand stabilized V1V2 immunogens elicit antibody responses with greater cross-reactivity.• Fine-tuning immunogen conformation modulates immunogenicity.
Keywords:
antibody;
v1v2 immunogens;
v1v2;
induction cross;
antibody responses
Journal Title: Vaccine
Year Published: 2020
Link to full text (if available)
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Journal Title: Vaccine
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!