Clonal myelopoiesis in the UK Biobank cohort: ASXL1 mutations are strongly associated with smoking
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-0896-8
Abstract: We sought to determine the significance of myeloid clonal hematopoiesis (CH) in the UK Biobank cohort ( n = 502,524, median age = 58 years). Utilizing SNP array ( n = 486,941) and whole exome sequencing data ( n… read more here.
Keywords: asxl1; smoking; biobank cohort; strongly associated ... See more keywords
Data-driven patient stratification of UK Biobank cohort suggests five endotypes of multimorbidity
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbac410
Abstract: Abstract Multimorbidity generally refers to concurrent occurrence of multiple chronic conditions. These patients are inherently at high risk and often lead a poor quality of life due to delayed treatments. With the emergence of personalized… read more here.
Keywords: endotypes multimorbidity; disease; stratification; multimorbidity ... See more keywords
Estimating the effect of physical activity on cognitive function within the UK Biobank cohort.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of epidemiology"
DOI: 10.1093/ije/dyad009
Abstract: BACKGROUND Physical activity (PA) has been associated with benefits for cognitive function (CF), but previous estimates of the strength of this relationship may have been biased due to limitations in statistical modelling practices that are… read more here.
Keywords: effect; cognitive function; physical activity; biobank cohort ... See more keywords
Canalization of the Polygenic Risk for Common Diseases and Traits in the UK Biobank Cohort
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac053
Abstract: Abstract Since organisms develop and thrive in the face of constant perturbations due to environmental and genetic variation, species may evolve resilient genetic architectures. We sought evidence for this process, known as canalization, through a… read more here.
Keywords: canalization; prevalence; polygenic risk; risk ... See more keywords
0024 The occupations at increased risk of copd in the uk biobank cohort
Sign Up to like & getrecommendations! Published in 2017 at "Occupational and Environmental Medicine"
DOI: 10.1136/oemed-2017-104636.14
Abstract: Background Occupational hazards are important, preventable causes of COPD but the high-risk occupations are uncertain. In an analysis of current occupation in the UK Biobank cohort we reported 14 jobs of increased risk (De Matteis,… read more here.
Keywords: risk; occupations increased; increased risk; biobank cohort ... See more keywords
Understanding cognitive impairment in mood disorders: mediation analyses in the UK Biobank cohort
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Psychiatry"
DOI: 10.1192/bjp.2019.188
Abstract: Background Cognitive impairment is strongly linked with persistent disability in people with mood disorders, but the factors that explain cognitive impairment in this population are unclear. Aims To estimate the total effect of (a) bipolar… read more here.
Keywords: disorder; mood disorders; biobank cohort; mood ... See more keywords
Socioeconomic Inequalities and Ethnicity Are Associated with a Positive COVID-19 Test among Cancer Patients in the UK Biobank Cohort
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13071514
Abstract: Simple Summary There is limited evidence regarding the influence of socioeconomic factors on COVID-19 transmission, severity and outcomes in the overall population. Furthermore, there is an urgent need to identify and explore the most important… read more here.
Keywords: risk; biobank cohort; incident cancer; cancer ... See more keywords