Atomistic Study of Intramolecular Interactions in the Closed-State Channelrhodopsin Chimera, C1C2.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.01.023
Abstract: Channelrhodopsins (ChR1 and ChR2) are light-activated ion channels that enable photomobility of microalgae from the genus Chlamydomonas. Despite common use of ChR2 in optogenetics for selective control and monitoring of individual neurons in living tissue,… read more here.
Keywords: chimera c1c2; closed state; c1c2; structure ... See more keywords
Twisting and Protonation of Retinal Chromophore Regulate Channel Gating of Channelrhodopsin C1C2.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c01879
Abstract: Channelrhodopsins (ChRs) are light-gated ion channels and central optogenetic tools that can control neuronal activity with high temporal resolution at the single-cell level. Although their application in optogenetics has rapidly progressed, it is unsolved how… read more here.
Keywords: retinal chromophore; c1c2; twisting protonation; chromophore ... See more keywords