Enantioselective binding of carvedilol to human serum albumin and alpha-1-acid glycoprotein.
Sign Up to like & getrecommendations! Published in 2023 at "Chirality"
DOI: 10.1002/chir.23595
Abstract: Carvedilol, a highly protein-bound beta-blocker, is used in therapy as a racemic mixture of its two enantiomers that exhibit different pharmacological activity. The aim of this study was to evaluate the stereoselective nature of its… read more here.
Keywords: carvedilol; acid glycoprotein; alpha acid;
Low-volume LC-MS/MS method for the pharmacokinetic investigation of carvedilol, enalapril and their metabolites in whole blood and plasma: application to a paediatric clinical trial.
Sign Up to like & getrecommendations! Published in 2020 at "Drug testing and analysis"
DOI: 10.1002/dta.2949
Abstract: Evidence-based pharmacotherapy with carvedilol and enalapril in children suffering from heart failure is insufficient owing to limited pharmacokinetic data.1 While a few datasets regarding enalapril, its metabolite enalaprilat and carvedilol in children have been published,… read more here.
Keywords: carvedilol; blood; whole blood; blood plasma ... See more keywords
Effect of Roux-En-Y Gastric Bypass In The Pharmacokinetics of (R)-Carvedilol and (S)-Carvedilol.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.2221
Abstract: Roux-en-Y gastric bypass (RYGB) is one of the most common surgical treatments for obesity due to the effective long-term weight loss and remission of associated comorbidities. Carvedilol, a third-generation β-blocker, is prescribed to treat cardiovascular… read more here.
Keywords: post rygb; roux gastric; rygb; gastric bypass ... See more keywords
Treatment with carvedilol improves survival of patients with acute-on-chronic liver failure: a randomized controlled trial
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology International"
DOI: 10.1007/s12072-019-09986-9
Abstract: Background and aimsIn addition to the portal pressure reducing effect, non-selective beta blockers (NSBBs) have possible immunomodulatory and effect in reducing bacterial translocation. Recently, it has been shown that patients who are already on NSBBs… read more here.
Keywords: chronic liver; liver failure; carvedilol; acute chronic ... See more keywords
Impact of the mucoadhesive lyophilized wafer loaded with novel carvedilol nano-spanlastics on biochemical markers in the heart of spontaneously hypertensive rat models
Sign Up to like & getrecommendations! Published in 2020 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-020-00814-4
Abstract: The purpose of this investigation was to encapsulate carvedilol, a model beta-blocker antihypertensive into nano-spanlastics, followed by incorporation into 1% CMC wafer to afford a mucoadhesive buccal drug delivery system, targeting to sidestep the first-pass… read more here.
Keywords: wafer; delivery; drug; carvedilol ... See more keywords
Carvedilol prevents pancreatic β-cell damage and the development of type 1 diabetes in mice by the inhibition of proinflammatory cytokines, NF-κB, COX-2, iNOS and oxidative stress.
Sign Up to like & getrecommendations! Published in 2020 at "Cytokine"
DOI: 10.1016/j.cyto.2020.155394
Abstract: Inflammation is one of the main mechanisms of pancreatic β-cell damage and the development of type 1 diabetes (T1D). Carvedilol, a beta-adrenergic receptor blocker, has been demonstrated to have anti-inflammatory and antioxidant effects. The aim… read more here.
Keywords: damage development; pancreatic cell; carvedilol; cell damage ... See more keywords
Enhancement of oral bioavailability of poorly water soluble carvedilol by chitosan nanoparticles: Optimization and pharmacokinetic study.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.05.162
Abstract: A major challenge associated with the oral delivery of anti-hypertensive drugs is their poor water solubility and low oral bioavailability. Carvedilol (CAR), a potential beta-blocker is hydrophobic drug that exhibit limited therapeutic effect through oral… read more here.
Keywords: oral bioavailability; water; chitosan nanoparticles; drug ... See more keywords
Vibrational spectroscopic and Hirshfeld surface analysis of carvedilol crystal forms
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DOI: 10.1016/j.ijpharm.2018.10.051
Abstract: &NA; The drug carvedilol, used to treat cardiovascular conditions, is known to exist in distinct crystalline forms. Polymorphs II and III and the hydrate are characterized by variations in their molecular packing and conformation. This… read more here.
Keywords: hirshfeld surface; surface; spectroscopic; carvedilol ... See more keywords
Hydrophilic nanofibers as a supersaturating delivery system for carvedilol.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120700
Abstract: Polymer nanofibers represent a promising delivery system for poorly water-soluble drugs; however, their supersaturating potential has not been explored yet. Here, carvedilol-loaded nanofibers based on poly(ethyleneoxide) and on amphiphilic block copolymer poloxamer 407 were produced… read more here.
Keywords: system; delivery system; hydrophilic nanofibers; carvedilol ... See more keywords
Carvedilol for Prevention of Chemotherapy-Related Cardiotoxicity: The CECCY Trial.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.02.049
Abstract: BACKGROUND Anthracycline (ANT) chemotherapy is associated with cardiotoxicity. Prevention with β-blockers remains controversial. OBJECTIVES This prospective, randomized, double-blind, placebo-controlled study sought to evaluate the role of carvedilol in preventing ANT cardiotoxicity. METHODS The authors randomized… read more here.
Keywords: chemotherapy; carvedilol group; cardiotoxicity; carvedilol ... See more keywords
Effects of carvedilol vs bisoprolol on inflammation and oxidative stress in patients with chronic heart failure.
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DOI: 10.1016/j.jjcc.2019.07.011
Abstract: BACKGROUND Inflammation and oxidative stress play a role in the pathophysiology of chronic heart failure (CHF). Our previous clinical trial, the Bisoprolol Improvement Group for Chronic Heart Failure Treatment Study in Dokkyo Medical University (BRIGHT-D),… read more here.
Keywords: oxidative stress; group; stress; carvedilol ... See more keywords