Targeting Epigenetic Regulatory Enzymes for Cancer Therapeutics: Novel Small-Molecule Epidrug Development
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.848221
Abstract: Dysregulation of the epigenetic enzyme-mediated transcription of oncogenes or tumor suppressor genes is closely associated with the occurrence, progression, and prognosis of tumors. Based on the reversibility of epigenetic mechanisms, small-molecule compounds that target epigenetic… read more here.
Keywords: small molecule; target epigenetic; enzymes cancer; regulatory enzymes ... See more keywords
The Transcription Factor NRF2 Has Epigenetic Regulatory Functions Modulating HDACs, DNMTs, and miRNA Biogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12030641
Abstract: The epigenetic regulation of gene expression is a complex and tightly regulated process that defines cellular identity and is associated with health and disease processes. Oxidative stress is capable of inducing epigenetic modifications. The transcription… read more here.
Keywords: factor nrf2; factor; biogenesis; epigenetic regulatory ... See more keywords
Epigenetic Regulatory Dynamics in Models of Methamphetamine-Use Disorder
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12101614
Abstract: Methamphetamine (METH)-use disorder (MUD) is a very serious, potentially lethal, biopsychosocial disease. Exposure to METH causes long-term changes to brain regions involved in reward processing and motivation, leading vulnerable individuals to engage in pathological drug-seeking… read more here.
Keywords: dynamics models; disorder; regulatory dynamics; epigenetic regulatory ... See more keywords