Intermittent fasting increases adult hippocampal neurogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Brain and Behavior"
DOI: 10.1002/brb3.1444
Abstract: Intermittent fasting (IF) has been suggested to have neuroprotective effects through the activation of multiple signaling pathways. Rodents fasted intermittently exhibit enhanced hippocampal neurogenesis and long‐term potentiation (LTP) at hippocampal synapses compared with sedentary animals… read more here.
Keywords: fasting increases; neurogenesis; hippocampal neurogenesis; intermittent fasting ... See more keywords
Evolution of genetic mechanisms regulating cortical neurogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22891
Abstract: The size of the cerebral cortex increases dramatically across amniotes, from reptiles to great apes. This is primarily due to different numbers of neurons and glial cells produced during embryonic development. The evolutionary expansion of… read more here.
Keywords: cortical neurogenesis; mechanisms regulating; neurogenesis; genetic mechanisms ... See more keywords
Seizure severity‐dependent selective vulnerability of the granule cell layer and aberrant neurogenesis in the rat hippocampus
Sign Up to like & getrecommendations! Published in 2017 at "Hippocampus"
DOI: 10.1002/hipo.22752
Abstract: The pilocarpine‐induced status epilepticus rodent model has been commonly used to analyze the mechanisms of human temporal lobe epilepsy. Recent studies using this model have demonstrated that epileptic seizures lead to increased adult neurogenesis of… read more here.
Keywords: granule cell; hippocampus; neurogenesis; layer ... See more keywords
Hippocampal neurogenesis promotes effortful responding but does not regulate effort‐based choice
Sign Up to like & getrecommendations! Published in 2022 at "Hippocampus"
DOI: 10.1002/hipo.23472
Abstract: A fundamental trait of depression is low motivation. Hippocampal neurogenesis has been associated with motivational deficits but detailed evidence on how it regulates human‐relevant behavioral traits is still missing. We used the hGFAP‐TK rat model… read more here.
Keywords: hippocampal neurogenesis; based choice; neurogenesis; effort based ... See more keywords
Epigenetic aging in adult neurogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Hippocampus"
DOI: 10.1002/hipo.23494
Abstract: Neural stem cells (NSCs) in the hippocampus generate new neurons throughout life, which functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal neurogenesis substantially declines with age and age‐related impairments in NSC activity… read more here.
Keywords: aging adult; adult neurogenesis; epigenetic aging; neurogenesis ... See more keywords
In vitro characterization on the role of APOE polymorphism in human hippocampal neurogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Hippocampus"
DOI: 10.1002/hipo.23502
Abstract: Hippocampal neurogenesis (HN) is considered an important mechanism underlying lifelong brain plasticity, and alterations in this process have been implicated in early Alzheimer's disease progression. APOE polymorphism is the most common genetic risk factor for… read more here.
Keywords: apoe polymorphism; polymorphism; role; neurogenesis ... See more keywords
Mechanisms underlying the effect of voluntary running on adult hippocampal neurogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Hippocampus"
DOI: 10.1002/hipo.23520
Abstract: Adult hippocampal neurogenesis is important for preserving learning and memory‐related cognitive functions. Physical exercise, especially voluntary running, is one of the strongest stimuli to promote neurogenesis and has beneficial effects on cognitive functions. Voluntary running… read more here.
Keywords: adult hippocampal; mechanisms underlying; neurogenesis; hippocampal neurogenesis ... See more keywords
Pterostilbene, an active component of the dragon’s blood extract, acts as an antidepressant in adult rats
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5138-7
Abstract: BackgroundHippocampal neurogenesis has been widely considered as one of the potential biological mechanisms for the treatment of depression caused by chronic stress. Many natural products have been reported to be beneficial for neurogenesis.ObjectivesThe present study… read more here.
Keywords: blood extract; neurogenesis; dragon blood; dbe pte ... See more keywords
Supporting Evidence of Human Enteric Nervous System Adult Neurogenesis: Presence of Primary Cilia and Adult Neurogenesis Markers.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-020-01017-8
Abstract: Adult neurogenesis has been profusely studied in central nervous system. However, its presence in enteric nervous system remains elusive although it has been recently demonstrated in mice and intimately linked to glial cells. Moreover, primary… read more here.
Keywords: neurogenesis; nervous system; adult neurogenesis; enteric nervous ... See more keywords
Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0785-y
Abstract: Adaptor proteins containing the pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif (APPLs) are multifunctional adaptor proteins involved in regulating many biological activities and processes. The newly identified metabolic factor APPL2 showed the… read more here.
Keywords: appl2; neurogenesis; hippocampal neurogenesis; glucocorticoid receptor ... See more keywords
Nuclear Receptor NR5A2 Promotes Neuronal Identity in the Adult Hippocampus.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02222-8
Abstract: Neurogenesis in the dentate gyrus (DG) of the adult hippocampus is actively involved in brain homeostasis. Thus, identification of novel regulators in adult neurogenesis could significantly contribute to new therapies. We have recently unraveled the… read more here.
Keywords: adult; neurogenesis; neuronal identity; nuclear receptor ... See more keywords