Pharmacologic inhibition of LAT1 predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells
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DOI: 10.1111/jcmm.17553
Abstract: L‐type amino acid transporter 1 (LAT1; SLC7A5), which preferentially transports large neutral amino acids, is highly upregulated in various cancers. LAT1 supplies cancer cells with amino acids as substrates for enhanced biosynthetic and bioenergetic reactions… read more here.
Keywords: amino acids; neutral amino; large neutral; cancer cells ... See more keywords
Identification and Characterization of Inhibitors of a Neutral Amino Acid Transporter, SLC6A19, Using Two Functional Cell-Based Assays
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DOI: 10.1177/2472555218794627
Abstract: SLC6A19 (B0AT1) is a neutral amino acid transporter, the loss of function of which results in Hartnup disease. SLC6A19 is also believed to have an important role in amino acid homeostasis, diabetes, and weight control.… read more here.
Keywords: neutral amino; amino acid; slc6a19; acid transporter ... See more keywords
Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods
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DOI: 10.3390/ijms20010027
Abstract: The large neutral amino acid transporter 1 (LAT1) is a promising anticancer target that is required for the cellular uptake of essential amino acids that serve as building blocks for cancer growth and proliferation. Here,… read more here.
Keywords: neutral amino; amino; amino acid; lat1 ... See more keywords
Large Neutral Amino Acids (LNAAs) Supplementation Improves Neuropsychological Performances in Adult Patients with Phenylketonuria
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DOI: 10.3390/nu12041092
Abstract: Phenylketonuria is an inborn error of phenylalanine (Phe) metabolism diagnosed by newborn screening and treated early with diet. Although diet prevents intellectual disability, patients often show impairment of executive functions, working memory, sustained attention, and… read more here.
Keywords: lnaas supplementation; supplementation; amino acids; acids lnaas ... See more keywords