Inter-phenotypic differences in CYP2C9 and CYP2C19 metabolism: Bayesian meta-regression of human population variability in kinetics and application in chemical risk assessment.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2020.11.016
Abstract: Quantifying variability in pharmacokinetics (PK) and toxicokinetics (TK) provides a science-based approach to refine uncertainty factors (UFs) for chemical risk assessment. In this context, genetic polymorphisms in cytochromes P450 (CYPs) drive inter-phenotypic differences and may… read more here.
Keywords: inter phenotypic; metabolism; variability; cyp2c9 cyp2c19 ... See more keywords
TFforge utilizes large-scale binding site divergence to identify transcriptional regulators involved in phenotypic differences
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky1200
Abstract: Abstract Changes in gene regulation are important for phenotypic and in particular morphological evolution. However, it remains challenging to identify the transcription factors (TFs) that contribute to differences in gene regulation and thus to phenotypic… read more here.
Keywords: binding site; phenotypic; phenotypic differences; site divergence ... See more keywords
Demographic and clinical phenotypic differences between people with dissociative seizures and those with other psychiatric disorders
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DOI: 10.1192/bjo.2021.18
Abstract: Background A large amount of literature surrounds the differences between dissociative neurological symptom disorder with non-epileptic seizures (DNSD-S) and epilepsy. Aims To explore the research gap on phenotypic differences between DNSD-S and other psychiatric disorders.… read more here.
Keywords: demographic clinical; clinical phenotypic; psychiatric disorders; phenotypic ... See more keywords
Phenotypic Differences Among Familial Partial Lipodystrophy Due to LMNA or PPARG Variants
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvac155
Abstract: Abstract Context Despite several reports of familial partial lipodystrophy (FPLD) type 2 (FPLD2) due to heterozygous LMNA variants and FPLD3 due to PPARG variants, the phenotypic differences among them remain unclear. Objective To compare the… read more here.
Keywords: familial partial; partial lipodystrophy; phenotypic differences; lipodystrophy ... See more keywords