In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105528
Abstract: Geranylgeranyl diphosphate synthase (GGDPS), an enzyme in the isoprenoid biosynthetic pathway (IBP), produces the isoprenoid (geranylgeranyl pyrophosphate, GGPP) used in protein geranylgeranylation reactions. Our prior studies utilizing triazole bisphosphonate-based GGDPS inhibitors (GGSIs) have revealed that… read more here.
Keywords: combination; protein geranylgeranylation; isoprenoid biosynthetic; therapy ... See more keywords
Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi
Sign Up to like & getrecommendations! Published in 2019 at "Virulence"
DOI: 10.1080/21505594.2019.1620063
Abstract: ABSTRACT Protein prenylation is a crucial post-translational modification largely mediated by two heterodimeric enzyme complexes, farnesyltransferase and geranylgeranyltransferase type-I (GGTase-I), each composed of a shared α-subunit and a unique β-subunit. GGTase-I enzymes are validated drug… read more here.
Keywords: protein geranylgeranylation; virulence; cell wall; subunit ... See more keywords
A Requirement of Protein Geranylgeranylation for Chemokine Receptor Signaling and Th17 Cell Function in an Animal Model of Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.641188
Abstract: Precisely controlled lymphocyte migration is critically required for immune surveillance and successful immune responses. Lymphocyte migration is strictly regulated by chemokines and chemokine receptors. Here we show that protein geranylgeranylation, a form of post-translational protein… read more here.
Keywords: receptor signaling; chemokine receptor; geranylgeranylation; protein geranylgeranylation ... See more keywords