4- Substituted sampangine derivatives: Novel acetylcholinesterase and β-myloid aggregation inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.10.157
Abstract: A series of 4- substituted sampangine derivatives (4-aminoalkylaminosampangine Ar-NH(CH2)nNR1R2) has been designed, synthesized, and tested for their ability to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and β-myloid (Aβ) aggregation. The synthetic compounds exhibited high AChE inhibitory… read more here.
Keywords: aggregation; sampangine derivatives; acetylcholinesterase; myloid aggregation ... See more keywords
Inhibitory potency of 4- substituted sampangine derivatives toward Cu2+ mediated aggregation of amyloid β-peptide, oxidative stress, and inflammation in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2020.104794
Abstract: Cu2+ plays a key role in the pathogenesis of Alzheimer's disease (AD). The dysregulation of Cu2+ can cause neuronal damage and aggravate development of AD. Moreover, a series of 4-substituted sampangine derivatives have been investigated… read more here.
Keywords: sampangine derivatives; cu2; alzheimer disease; cu2 mediated ... See more keywords