Photoconversion of FM1-43 Reveals Differences in Synaptic Vesicle Recycling and Sensitivity to Pharmacological Disruption of Actin Dynamics in Individual Synapses.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00712
Abstract: The cycling of synaptic vesicles ensures that neurons can communicate adequately through their synapses on repeated occasions when activity is sustained, and several steps in this cycle are modulated by actin. The effects of pharmacological… read more here.
Keywords: vesicle; actin; vesicle recycling; photoconversion ... See more keywords
Strain‐Dependent Effects of Acute Alcohol on Synaptic Vesicle Recycling and Post‐Tetanic Potentiation in Medial Glutamate Inputs to the Mouse Basolateral Amygdala
Sign Up to like & getrecommendations! Published in 2017 at "Alcoholism: Clinical and Experimental Research"
DOI: 10.1111/acer.13343
Abstract: BACKGROUND Inbred mouse strains are differentially sensitive to the acute effects of ethanol (EtOH) and are useful tools for examining how unique genomes differentially affect alcohol-related behaviors and physiology. DBA/2J mice have been shown to… read more here.
Keywords: vesicle; frequency; stimulation; vesicle recycling ... See more keywords
Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess α-Synuclein at Synapses
Sign Up to like & getrecommendations! Published in 2020 at "eNeuro"
DOI: 10.1523/eneuro.0448-19.2020
Abstract: α-Synuclein overexpression and aggregation are linked to Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and several other neurodegenerative disorders. In addition to effects in the cell body, α-synuclein accumulation occurs at presynapses where the… read more here.
Keywords: excess synuclein; synaptic vesicle; vesicle recycling; recycling defects ... See more keywords
The Structural Basis of Long-Term Potentiation in Hippocampal Synapses, Revealed by Electron Microscopy Imaging of Lanthanum-Induced Synaptic Vesicle Recycling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.920360
Abstract: Hippocampal neurons in dissociated cell cultures were exposed to the trivalent cation lanthanum for short periods (15–30 min) and prepared for electron microscopy (EM), to evaluate the stimulatory effects of this cation on synaptic ultrastructure.… read more here.
Keywords: synaptic vesicle; vesicle recycling; electron microscopy; microscopy ... See more keywords
pOpsicle: An all-optical reporter system for synaptic vesicle recycling combining pH-sensitive fluorescent proteins with optogenetic manipulation of neuronal activity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1120651
Abstract: pH-sensitive fluorescent proteins are widely used to study synaptic vesicle (SV) fusion and recycling. When targeted to the lumen of SVs, fluorescence of these proteins is quenched by the acidic pH. Following SV fusion, they… read more here.
Keywords: synaptic vesicle; fluorescent proteins; vesicle recycling; popsicle ... See more keywords
α-Synuclein: A Multifunctional Player in Exocytosis, Endocytosis, and Vesicle Recycling
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.00028
Abstract: α-synuclein (α-Syn) is a presynaptic enriched protein involved in the pathogenesis of Parkinson’s disease. However, the physiological roles of α-Syn remain poorly understood. Recent studies have indicated a critical role of α-Syn in the sensing… read more here.
Keywords: exocytosis endocytosis; exocytosis; endocytosis vesicle; vesicle recycling ... See more keywords
Effects of the clathrin inhibitor Pitstop-2 on synaptic vesicle recycling at a central synapse in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2022.1056308
Abstract: Four modes of endocytosis and subsequent synaptic vesicle (SV) recycling have been described at the presynapse to ensure the availability of SVs for synaptic release. However, it is unclear to what extend these modes operate… read more here.
Keywords: synaptic vesicle; vesicle recycling; clathrin inhibitor; effects clathrin ... See more keywords
Synaptic Vesicle Recycling and the Endolysosomal System: A Reappraisal of Form and Function
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2022.826098
Abstract: The endolysosomal system is present in all cell types. Within these cells, it performs a series of essential roles, such as trafficking and sorting of membrane cargo, intracellular signaling, control of metabolism and degradation. A… read more here.
Keywords: synaptic vesicle; system; endolysosomal system; vesicle recycling ... See more keywords