Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi-resistant Melanoma
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DOI: 10.1158/1078-0432.ccr-19-2773
Abstract: Purpose: The extracellular matrix (ECM) is an intriguing, yet understudied component of therapy resistance. Here, we investigated the role of ECM remodeling by the collagenase, MT1-MMP, in conferring resistance of v-Raf murine sarcoma viral oncogene… read more here.
Keywords: brafi resistant; mmp; mt1 mmp; inhibition ... See more keywords
NECTIN4: A Novel Therapeutic Target for Melanoma
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DOI: 10.3390/ijms22020976
Abstract: Malignant melanoma is the most common lethal skin cancer and causes death in a short time when metastasized. Although BRAF inhibitors (BRAFi) have greatly improved the prognosis of BRAF-mutated melanoma, drug resistance is a major… read more here.
Keywords: melanoma; nectin4 novel; brafi; brafi resistant ... See more keywords