Molecular CrossâTalk between Nonribosomal Peptide Synthetase Carrier Proteins and Unstructured Linker Regions
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700030
Abstract: Nonribosomal peptide synthetases (NRPSs) employ multiple domains separated by linker regions to incorporate substrates into natural products. During synthesis, substrates are covalently tethered to carrier proteins that translocate between catalytic partner domains. The molecular parameters… read more here.
Keywords: linker regions; carrier; linker; nonribosomal peptide ... See more keywords
Linker Domains: Why ABC Transporters 'Live in Fragments no Longer'.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2019.11.004
Abstract: ATP-binding cassette (ABC) transporters are membrane proteins present in all kingdoms of life. We have considered the disordered region that connects the N- and C-terminal halves in many eukaryotic ABC transporters, allowing all four consensus… read more here.
Keywords: domains abc; abc transporters; linker domains; transporters live ... See more keywords
Identification and Characterization of a Minimal Functional Splicing Regulatory Protein, PTBP1.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00664
Abstract: Polypyrimidine tract binding protein 1 (PTBP1) is a well-studied RNA binding protein that serves as an important model for understanding molecular mechanisms underlying alternative splicing regulation. PTBP1 has four RNA binding domains (RBDs) connected via… read more here.
Keywords: minimal functional; ptbp1; protein ptbp1; target ... See more keywords