SFTS bunyavirus NSs protein sequestrates mTOR into inclusion bodies and deregulates mTOR‐ULK1 signaling, provoking pro‐viral autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28371
Abstract: Autophagy is emerging as a critical player in host defense against diverse infections, in addition to its conserved function to maintain cellular homeostasis. Strikingly, some pathogens have evolved strategies to evade, subvert or exploit different… read more here.
Keywords: mtor ulk1; viral autophagy; pro viral; inclusion bodies ... See more keywords
Rapamycin Alleviates Hormone Imbalance-Induced Chronic Nonbacterial Inflammation in Rat Prostate Through Activating Autophagy via the mTOR/ULK1/ATG13 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0786-7
Abstract: Chronic prostatitis (CP) is a clinically common disease with high morbidity. It affects the patients’ quality of life (QoL) as well as physical and mental health seriously due to the recurring symptoms of lower urinary… read more here.
Keywords: mtor ulk1; atg13 signaling; ulk1 atg13; signaling pathway ... See more keywords
High glucose downregulates the effects of autophagy on osteoclastogenesis via the AMPK/mTOR/ULK1 pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.052
Abstract: Diabetes is a chronic disease that disrupts the balance between bone formation and bone desorption, which can lead to osteoporosis, increasing the risk of fracture. However, compared with osteoblasts, the biological effects of hyperglycemia on… read more here.
Keywords: mtor ulk1; microscopy; ampk mtor; autophagy osteoclastogenesis ... See more keywords
Walnut-Derived Peptides Promote Autophagy via the Activation of AMPK/mTOR/ULK1 Pathway to Ameliorate Hyperglycemia in Type 2 Diabetic Mice.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c07112
Abstract: Autophagy flux plays a significant protective role in type 2 diabetes mellitus (T2DM). However, the mechanisms by which autophagy mediates insulin resistance (IR) to ameliorate T2DM remain unclear. This study explored the hypoglycemic effects and… read more here.
Keywords: ulk1 pathway; mtor ulk1; ampk mtor; walnut derived ... See more keywords
Artemisinin attenuated atherosclerosis in high-fat diet-fed ApoE-/- mice by promoting macrophage autophagy via AMPK/mTOR/ULK1 pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000794
Abstract: Artemisinin is an endoperoxide sesquiterpene lactone from Artemisia annua L with multiple beneficial effects, including anti-inflammation, anti-oxidant and vascular protection. Recent studies have found that inflammation along with autophagy deficiency in macrophages are the possible… read more here.
Keywords: macrophage; macrophage autophagy; artemisinin; mtor ulk1 ... See more keywords
Aurora-B knockdown inhibits osteosarcoma metastasis by inducing autophagy via the mTOR/ULK1 pathway
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Cell International"
DOI: 10.1186/s12935-020-01674-1
Abstract: Background Autophagy plays an essential role in metastasis of malignancies. Although our studies showed that Aurora-B facilitate pulmonary metastasis in OS, the mechanism of Aurora-B kinase on autophagy and metastasis in OS has not been… read more here.
Keywords: mtor ulk1; ulk1 pathway; microscopy; metastasis ... See more keywords