Evaluating the Occurrence of Rare Variants in the Complement Factor H Gene in Patients With Early-Onset Drusen Maculopathy.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2021.4102
Abstract: Importance Early-onset drusen maculopathy (EODM) is a severe disease and can lead to advanced macular degeneration early in life; however, genetic and phenotypic characteristics of individuals with EODM are not well studied. Objective To identify… read more here.
Keywords: early onset; age; factor; gene ... See more keywords
Patients with MPNs and retinal drusen show signs of complement system dysregulation and a high degree of chronic low-grade inflammation
Sign Up to like & getrecommendations! Published in 2022 at "EClinicalMedicine"
DOI: 10.1016/j.eclinm.2021.101248
Abstract: Summary Background The hematopoietic stem cell disorders, myeloproliferative neoplasms (MPNs), are characterised by chronic low-grade inflammation (CLI). Recently, we showed that patients with MPNs have an increased prevalence of drusen and age-related macular degeneration (AMD),… read more here.
Keywords: chronic low; cli; inflammation; drusen ... See more keywords
Fuchs endothelial corneal dystrophy and macular drusen: evidence for coincidence?
Sign Up to like & getrecommendations! Published in 2018 at "Eye"
DOI: 10.1038/eye.2017.301
Abstract: The corneal endothelium and the retinal pigment epithelium represent monolayers of postmitotic polygonal cells of neuroectodermal origin with barrier and transport function. Fuchs endothelial corneal dystrophy (FECD) and age-related macular degeneration (AMD) show interesting similarities… read more here.
Keywords: corneal; fecd; presence; age ... See more keywords
Automated Retinal Layer Segmentation Using Graph-based Algorithm Incorporating Deep-learning-derived Information
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-66355-5
Abstract: Regular drusen, an accumulation of material below the retinal pigment epithelium (RPE), have long been established as a hallmark early feature of nonneovascular age-related macular degeneration (AMD). Advances in imaging have expanded the phenotype of… read more here.
Keywords: regular drusen; segmentation; retinal layers; drusen rpd ... See more keywords
PATTERN AND CHARACTERISTICS OF DRUSEN SUBTYPES IN CHINESE AND INDIAN POPULATIONS IN SINGAPORE
Sign Up to like & getrecommendations! Published in 2023 at "Retina"
DOI: 10.1097/iae.0000000000003651
Abstract: Supplemental Digital Content is Available in the Text. This study summarized the pattern and characteristics of drusen subtypes in East and South Asian populations. The systemic parameters, choroidal thickness, and volume are compared among eyes… read more here.
Keywords: pattern characteristics; drusen subtypes; choroidal thickness; characteristics drusen ... See more keywords
Photobiomodulation therapy for large soft drusen and drusenoid pigment epithelial detachment in age-related macular degeneration: a single-center prospective pilot study.
Sign Up to like & getrecommendations! Published in 2023 at "Retina"
DOI: 10.1097/iae.0000000000003805
Abstract: PURPOSE To evaluate visual acuity and morphologic changes after photobiomodulation (PBM) for patients affected with large soft drusen and/or drusenoid pigment epithelial detachment (dPED) associated to dry age-related macular degeneration (AMD). METHOD Twenty eyes with… read more here.
Keywords: pigment epithelial; large soft; drusen drusenoid; soft drusen ... See more keywords
Cuticular drusen presenting with central serous chorioretinopathy in both eyes: A case report
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000032032
Abstract: Rationale: Drusen are precursor lesions to advanced age-related macular degeneration. Although cuticular drusen are located between the retinal pigment epithelium and Bruch’s membrane, as are conventional drusen, they possess unique characteristics that are distinct from… read more here.
Keywords: csc; drusen presenting; cuticular drusen; drusen ... See more keywords
Inter-Device Comparison of Blue-Light Autofluorescence in Optic Disc Drusen
Sign Up to like & getrecommendations! Published in 2019 at "Ophthalmologica"
DOI: 10.1159/000501860
Abstract: Purpose: Monochromatic blue-light fundus autofluorescence has proven to be particularly useful for the detection of optic disc drusen (ODD). The aim of this study was to investigate how accurately novel confocal scanners can detect ODD… read more here.
Keywords: blue light; optic disc; autofluorescence; disc drusen ... See more keywords
Heritability and Risk Factors of Incident Small and Large Drusen in the Copenhagen Twin Cohort Eye Study: A 20-Year Follow-Up
Sign Up to like & getrecommendations! Published in 2022 at "Ophthalmologica"
DOI: 10.1159/000525652
Abstract: Introduction: The transition from a normal fundus to one with early drusen (≥20 small hard drusen) to age-related macular degeneration (AMD) in the form of drusen ≥63 μm in diameter is of interest, because small… read more here.
Keywords: small hard; hard drusen; eye; large drusen ... See more keywords
Clear subretinal fluid in a case of non-neovascular early-onset drusen: Swept-source imaging evaluation.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of ophthalmology"
DOI: 10.1177/1120672120957590
Abstract: A 50-year-old male presented with recent metamorphopsia in the right eye. Fundus examination revealed bilateral multiple cuticular drusen along with few large colloid drusen (phenotype 3 cuticular drusen). No vitelliform material was evident in the… read more here.
Keywords: onset drusen; early onset; swept source; clear subretinal ... See more keywords
Drusen and pigment abnormality predict the development of neovascular age-related macular degeneration in Japanese patients
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0255213
Abstract: Drusen are known to be the important hallmark to predict the development of age-related macular degeneration (AMD). The prevalence of drusen is lower in Asians compared with Caucasians so that the role of signs constituting… read more here.
Keywords: category; predict development; abnormality; amd ... See more keywords