Active unfolding of the glucocorticoid receptor by the Hsp70/Hsp40 chaperone system in single-molecule mechanical experiments
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2119076119
Abstract: Significance One of the key unresolved questions in the field of molecular chaperones is how they can actively unfold proteins. In this study, we discovered that the Hsp70/Hsp40 chaperone system completely unfolds a native soluble… read more here.
Keywords: hsp70 hsp40; receptor; hsp70; hsp40 chaperone ... See more keywords
The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202113952
Abstract: Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer’s disease (AD). However, the etiology of its noxious cellular effects remains elusive. In a combinatory genetic and proteomic approach using a yeast model… read more here.
Keywords: amyloid beta; hsp40 chaperone; toxicity; ydj1 ... See more keywords