Facile Preparation of UFMylation Activity-Based Probes by Chemoselective Installation of Electrophiles at the C-Terminus of Recombinant UFM1
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DOI: 10.1021/acscentsci.2c00203
Abstract: Aberrations in protein modification with ubiquitin-fold modifier (UFM1) are associated with a range of diseases, but the biological function and regulation of this post-translational modification, known as UFMylation, remain enigmatic. To provide activity-based probes for… read more here.
Keywords: terminus recombinant; based probes; ufmylation; activity based ... See more keywords
UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis
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DOI: 10.1038/s41422-019-0236-6
Abstract: Protein biogenesis at the endoplasmic reticulum (ER) in eukaryotic cells is monitored by a protein quality control system named ER-associated protein degradation (ERAD). While there has been substantial progress in understanding how ERAD eliminates defective… read more here.
Keywords: protein; quality control; translocation; ufmylation ... See more keywords
Dysregulation of PD-L1 by UFMylation imparts tumor immune evasion and identified as a potential therapeutic target.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2215732120
Abstract: Immunotherapy of PD-L1/PD-1 blockage elicited impressive clinical benefits for cancer treatment. However, the relative low response and therapy resistance highlight the need to better understand the molecular regulation of PD-L1 in tumors. Here, we report that… read more here.
Keywords: dysregulation ufmylation; therapeutic target; ufmylation imparts; ufmylation ... See more keywords
Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation
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DOI: 10.1101/2022.02.28.482207
Abstract: An essential first step in the posttranslational modification of proteins with UFM1, UFMylation, is the proteolytic cleavage of pro-UFM1 to expose a C-terminal glycine. Of the two UFM1-specific proteases (UFSPs) identified in humans, only UFSP2… read more here.
Keywords: ufm1 maturation; protease; human ufsp1; ufmylation ... See more keywords
Ufl1 deficiency causes skin pigmentation by up-regulation of Endothelin-1
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DOI: 10.3389/fcell.2022.961675
Abstract: Ufmylation (UFM1 modification) is a newly identified ubiquitin-like modification system involved in numerous cellular processes. However, the regulatory mechanisms and biological functions of this modification remain mostly unknown. We have recently reported that Ufmylation family… read more here.
Keywords: modification; ufl1 deficiency; skin pigmentation; ufmylation ... See more keywords