Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.43232
Abstract: Key Points Question What is the association between Klotho protein levels in cerebrospinal fluid (CSF) and plasma, heterozygosity status of the KL-VS haplotype, and amyloid and tau burden among cognitively healthy controls and patients with… read more here.
Keywords: amyloid tau; heterozygosity; protein levels; klotho protein ... See more keywords
αKlotho protein has therapeutic activity in contrast-induced acute kidney injury by limiting NLRP3 inflammasome-mediated pyroptosis and promoting autophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105531
Abstract: Contrast-induced acute kidney injury (CI-AKI) is a main cause of hospital-acquired renal failure. Nevertheless, limited measures have been shown to be effective for the treatment of CI-AKI. Here, we demonstrated that αKlotho, which is highly… read more here.
Keywords: contrast; pyroptosis; contrast induced; klotho protein ... See more keywords
Klotho protein, albumin level, left ventricular and left atrium dimensions are independently associated with moderate and severe cardiac allograft vasculopathy in heart transplant recipients
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.2698
Abstract: Cardiac allograft vasculopathy (CAV) is one of the main risk factors influencing graft loss and patients survival. An important element of monitoring the patient after heart transplantation (HT) is the assessment of non-invasive indicators associated… read more here.
Keywords: heart; moderate severe; left atrium; klotho protein ... See more keywords
Klotho suppresses the renin-angiotensin system in adriamycin nephropathy
Sign Up to like & getrecommendations! Published in 2017 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfw340
Abstract: Backgrounds Klotho protein interacts with the transforming growth factor β (TGF-β) receptor and Wnt, which contribute to the progression of renal disease, inhibiting their signals. Renal and circulating klotho levels are diminished in chronic kidney… read more here.
Keywords: catenin angiotensin; adriamycin nephropathy; angiotensin; expression ... See more keywords
Astaxanthin extenuates the inhibition of aldehyde dehydrogenase and Klotho protein expression in cyclophosphamide‐induced acute cardiomyopathic rat model
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13598
Abstract: This study evaluated the mechanistic sequel of aldehyde dehyrogenase (ALDH2) and Klotho protein in cyclophosphamide (CP)‐induced cardiotoxicity in rats and the protective effect of astaxanthin (AST) against that sequel. A total of 40 male Wistar… read more here.
Keywords: klotho protein; protein; group; protein expression ... See more keywords
Therapeutic Challenge of Minicircle Vector Encoding Klotho in Animal Model
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Nephrology"
DOI: 10.1159/000499863
Abstract: Background: Klotho treatment is a promising approach against kidney injury, but its clinical application is still undetermined. We developed a novel strategy to allow self-production of Klotho protein, using minicircle (MC) technology, and evaluated its… read more here.
Keywords: production klotho; klotho; model; klotho protein ... See more keywords
Klotho Ameliorates Medullary Fibrosis and Pressure Natriuresis in Hypertensive Rat Kidneys
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DOI: 10.1161/hypertensionaha.118.11176
Abstract: Renal expression of klotho is reduced in hypertension. Experiments were performed to examine whether exogenous klotho protein supplementation ameliorates pressure natriuresis in early phase of hypertension, using stroke-prone spontaneously hypertensive rats (sp-SHR). The interactions between… read more here.
Keywords: supplementation; pressure natriuresis; klotho protein; klotho ... See more keywords
Association between Soluble α-Klotho Protein and Metabolic Syndrome in the Adult Population
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DOI: 10.3390/biom12010070
Abstract: Klotho protein is an anti-aging protein and plays multiple roles in ion-regulation, anti-oxidative stress, and energy metabolism through various pathways. Metabolic syndrome is a combination of multiple conditions that compose of multiple risk factors of… read more here.
Keywords: metabolic syndrome; soluble klotho; klotho protein; protein ... See more keywords
Klotho Protein Decreases MMP-Mediated Degradation of Contractile Proteins during Ischaemia/Reperfusion Injury to the Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415450
Abstract: Ischaemia, followed by reperfusion, causes the generation of reactive oxygen species, overproduction of peroxynitrite, activation of matrix metalloproteinases (MMPs), and subsequently the degradation of heart contractile proteins in the cardiomyocytes. Klotho is a membrane-bound or… read more here.
Keywords: degradation contractile; reperfusion; contractile proteins; klotho protein ... See more keywords
The association of klotho protein and nutrition status for maintenance hemodialysis patients
Sign Up to like & getrecommendations! Published in 2019 at "International Urology and Nephrology"
DOI: 10.3760/cma.j.issn.1673-4416.2019.03.038
Abstract: Objective To explore the association between klotho protein and nutrition status for maintenance hemodialysis patients. Methods From June 2016 to November 2016, 100 patients who received maintenance hmodialysis were divided into three groups, group A:… read more here.
Keywords: nutrition status; klotho protein; group;
Klotho protein function among patients with type 1 diabetes.
Sign Up to like & getrecommendations! Published in 2018 at "Endokrynologia Polska"
DOI: 10.5603/ep.a2018.0070
Abstract: The fibroblast growth factor 23 (FGF23) and Klotho system play a very important role in the regulation of the human body metabolism. On the one hand, they promote longevity, and on the other hand they… read more here.
Keywords: protein function; type diabetes; fgf23 klotho; chronic complications ... See more keywords