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   Articles with "stk25" as a keyword



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Downregulation of STK25 promotes autophagy via the Janus kinase 2/signal transducer and activator of transcription 3 pathway in colorectal cancer

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recommendations! Published in 2022 at "Molecular Carcinogenesis"

DOI: 10.1002/mc.23403

Abstract: Autophagy plays a crucial role in colorectal cancer (CRC) development. Our previous study suggested that serine/threonine protein kinase 25 (STK25) regulates aerobic glycolysis in CRC cells. Glycolysis modulates cellular autophagy during tumor growth; however, the… read more here.

Keywords: downregulation stk25; stk25; crc; colorectal cancer ... See more keywords
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Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease.

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recommendations! Published in 2020 at "JCI insight"

DOI: 10.1172/jci.insight.140483

Abstract: Diabetic kidney disease (DKD) is the most common cause of severe renal disease worldwide and the single strongest predictor of mortality in diabetes patients. Kidney steatosis has emerged as a critical trigger in the pathogenesis… read more here.

Keywords: disease; diabetic kidney; renal lipotoxicity; stk25 ... See more keywords
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Exosomal miR-4800-3p Aggravates the Progression of Hepatocellular Carcinoma via Regulating the Hippo Signaling Pathway by Targeting STK25

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recommendations! Published in 2022 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2022.759864

Abstract: Background Emerging evidence has shown that exosome microRNAs (miRNAs) regulate the development of hepatocellular carcinoma (HCC). Here, the influences of miR-4800-3p on the progression of HCC were explored. Materials and Methods The expression of miR-4800-3p… read more here.

Keywords: hepatocellular carcinoma; mir 4800; stk25; hcc ... See more keywords
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STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism

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recommendations! Published in 2020 at "eLife"

DOI: 10.7554/elife.54863

Abstract: The MST-LATS kinase cascade is central to the Hippo pathway that controls tissue homeostasis, development, and organ size. The PP2A complex STRIPAKSLMAP blocks MST1/2 activation. The GCKIII family kinases associate with STRIPAK, but the functions… read more here.

Keywords: stripak; hippo signaling; stk25 suppresses; antagonism ... See more keywords