Phase 2 study for nonmetastatic extremity high-grade osteosarcoma in pediatric and adolescent and young adult patients with a risk-adapted strategy based on ABCB1/P-glycoprotein expression: An Italian Sarcoma Group trial (ISG/OS-2).
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DOI: 10.1002/cncr.34131
Abstract: BACKGROUND According to retrospective osteosarcoma series, ABCB1/P-glycoprotein (Pgp) overexpression predicts for poor outcomes. A prospective trial to assess a risk-adapted treatment strategy using mifamurtide in Pgp+ patients was performed. METHODS This was a phase 2,… read more here.
Keywords: abcb1 glycoprotein; osteosarcoma; trial; nonmetastatic extremity ... See more keywords
Adherence to a risk‐adapted screening strategy for prostate cancer: First results of the PROBASE trial
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DOI: 10.1002/ijc.34295
Abstract: PROBASE is a population‐based, randomized trial of 46 495 German men recruited at age 45 to compare effects of risk‐adapted prostate cancer (PCa) screening starting either immediately at age 45, or at a deferred age of… read more here.
Keywords: risk; strategy; psa; risk adapted ... See more keywords
[Current controversies in risk-adapted therapy in differentiated thyroid cancer: Is less (therapy) really more?]
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DOI: 10.1007/s10354-019-00713-5
Abstract: In recent years, there has been worldwide a significant (relative) increase in "small" thyroid cancer (pT1 = tumor size of ≤10 mm), which has now reached a plateau. This fact and the absence of prospective and randomized clinical trials are… read more here.
Keywords: therapy; differentiated thyroid; thyroid cancer; cancer ... See more keywords
Cost-effectiveness Analysis of Non-risk-adapted Active Surveillance for Postorchiectomy Management of Clinical Stage I Seminoma.
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DOI: 10.1016/j.euf.2020.06.012
Abstract: BACKGROUND Cancer-specific survival for men with clinical stage I (CSI) seminoma approaches 100%, regardless of the management approach chosen after orchiectomy. Given the young age and high survival rate of these patients, there has been… read more here.
Keywords: active surveillance; treatment; management; cost ... See more keywords
Risk‐adapted bendamustine + rituximab is a tolerable treatment alternative for elderly patients with chronic lymphocytic leukaemia: a regional real‐world report on 141 consecutive Swedish patients
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DOI: 10.1111/bjh.17032
Abstract: Bendamustine + rituximab (BR) is the current first‐line standard‐of‐care for chronic lymphocytic leukaemia (CLL) in fit patients aged 66–70 years, whereas chlorambucil + CD20 antibody is recommended in older patients with co‐morbidities. This retrospective real‐world… read more here.
Keywords: real world; line; lymphocytic leukaemia; bendamustine rituximab ... See more keywords
Head‐to‐head comparison of a risk‐adapted screening strategy using various risk prediction models in detecting colorectal neoplasm
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DOI: 10.1111/jgh.15825
Abstract: The risk‐adapted screening strategy showed satisfying colorectal cancer (CRC) screening yield and efficiency. We therefore further explored the diagnostic performance variation of this strategy using different risk prediction models. read more here.
Keywords: screening strategy; head; adapted screening; risk ... See more keywords
Study protocol of the RaPS study: novel risk adapted prevention strategies for people with a family history of colorectal cancer
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DOI: 10.1186/s12885-018-4646-5
Abstract: BackgroundPeople aged 40–60 years with a family history (FH) of colorectal cancer (CRC) in 1st degree relatives (FDRs) have a 2- to 4-fold increased risk of CRC compared to the average risk population. Therefore, experts recommend… read more here.
Keywords: risk; study; crc; cancer ... See more keywords
Defining risk of micrometastatic disease and tumor recurrence in patients with stage I testicular germ cell tumors.
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DOI: 10.21037/tau.2019.06.20
Abstract: There is controversy in the management of patients with clinical stage I non-seminomatous germ cell tumor (NSGCT). Some experts recommend surveillance for all patients regardless of risk factors while others suggest a more risk-adapted approach… read more here.
Keywords: risk; risk adapted; defining risk; tumor ... See more keywords
Risk-Adapted Postmastectomy Radiotherapy Decision Based on Prognostic Nomogram for pT1-2N1M0 Breast Cancer: A Multicenter Study
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DOI: 10.3389/fonc.2020.588859
Abstract: Purpose The aim of this study was to develop a widely accepted prognostic nomogram and establish a risk-adapted PMRT strategy based on locoregional recurrence for pT1-2N1M0 breast cancer. Methods and Materials A total of 3,033… read more here.
Keywords: risk; breast cancer; 2n1m0 breast; pt1 2n1m0 ... See more keywords
[Comparison of application effects of colonoscopy, fecal immunochemical test and a novel risk-adapted screening approach in colorectal cancer screening in Xuzhou population].
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DOI: 10.3760/cma.j.cn112150-20211203-01113
Abstract: Objective: To compare the application effect of the colonoscopy, fecal immunochemical test (FIT) and novel risk-adapted screening approach in colorectal cancer screening in Xuzhou population. Methods: From May 2018 to April 2019, 4 280 subjects… read more here.
Keywords: adapted screening; group; risk; novel risk ... See more keywords