Analysis of genomic and immune intratumor heterogeneity in linitis plastica via multiregional exome and T-cell-receptor sequencing.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13381
Abstract: The molecular landscape and the intratumor heterogeneity (ITH) architecture of gastric linitis plastica (LP) are poorly understood. We performed whole-exome sequencing (WES) and T-cell receptor (TCR) sequencing on 40 tumor regions from four LP patients.… read more here.
Keywords: cell receptor; cell; intratumor heterogeneity; linitis plastica ... See more keywords
A simple twist of phosphate: Immunological synapse formation and T cell receptor signaling outcome in regulatory T cells
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201747359
Abstract: Signaling through the T cell receptor (TCR) regulates T cell homeostasis and effector functions. However, a full accounting of the TCR‐coupled signaling networks and how their interplay determines specific functional outcomes remains elusive. Of particular… read more here.
Keywords: treg; regulatory cells; cell receptor; cell ... See more keywords
Characterization of T‐cell receptor transgenic mice recognizing immunodominant HLA‐DQ2.5‐restricted gluten epitopes
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048859
Abstract: We created a TCR transgenic mouse with CD4+ T cells recognizing the immunodominant DQ2.5-glia-ω2 gluten epitope. We show that these cells respond to deamidated gluten feed in vivo and compare them to previously published α2-… read more here.
Keywords: dq2; recognizing immunodominant; receptor transgenic; characterization cell ... See more keywords
Comprehensive analysis of T‐cell receptor repertoires reveals antigen‐driven T‐cell clusters in patients with Behçet's syndrome
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202250181
Abstract: T lymphocytes are the major components of adaptive immunity in Behçet's syndrome (BS) pathology. However, the precise mechanism of T‐cell‐induced inflammatory condition remains to be determined. We applied bulk sequencing of the T‐cell receptor (TCR)… read more here.
Keywords: analysis cell; cell; beh syndrome; cell receptor ... See more keywords
Intrahepatic T‐Cell Receptor β Immune Repertoire Is Essential for Liver Regeneration
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30067
Abstract: T lymphocytes synergize with the cellular immune system to promote hepatocyte regeneration. The T‐cell receptor (TCR) immune repertoire is closely associated with the host immune response and regenerative proliferation. High‐throughput sequencing of TCR provides deep… read more here.
Keywords: immune repertoire; liver regeneration; regeneration; cell receptor ... See more keywords
LncRNA FIRRE stimulates PTBP1‐induced Smurf2 decay, stabilizes B‐cell receptor, and promotes the development of diffuse large B‐cell lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "Hematological Oncology"
DOI: 10.1002/hon.3004
Abstract: Sustained expression of B‐cell receptor (BCR) critically contributes to the development of diffuse large B‐cell lymphoma (DLBCL). However, little is known on the mechanism regulating BCR expression. In the present study, we explored the biological… read more here.
Keywords: cell; development; dlbcl; decay ... See more keywords
T Cell Receptor Repertoire Sequencing.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0904-0_1
Abstract: The status of T cell receptors (TCRs) repertoire is associated with the occurrence and progress of various diseases and can be used in monitoring the immune responses, predicting the prognosis of disease and other medical… read more here.
Keywords: cell receptor; repertoire sequencing; biology; repertoire ... See more keywords
Understanding of B Cell Receptor Signaling Through a Photo-Activatable Antigen Presentation System.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7474-0_16
Abstract: Antibody responses are initiated by the binding of antigens to cell surface expressed B cell receptors (BCRs) that trigger signaling cascades resulting in the activation of B cells. However, it has been difficult to study… read more here.
Keywords: understanding cell; system; cell receptor; antigen ... See more keywords
An Economical, Quantitative, and Robust Protocol for High-Throughput T Cell Receptor Sequencing from Tumor or Blood.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8885-3_2
Abstract: The T cell receptor repertoire provides a window to the cellular adaptive immune response within a tumor, and has the potential to identify specific and personalized biomarkers for tracking host responses during cancer therapy, including… read more here.
Keywords: protocol; cell receptor; blood; cell ... See more keywords
PCR GeneScan and Heteroduplex Analysis of Rearranged Immunoglobulin or T-Cell Receptor Genes for Clonality Diagnostics in Suspect Lymphoproliferations.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9151-8_4
Abstract: Assessment of the presence of clonal lymphoproliferations via polymerase chain reaction (PCR)-based analysis of rearranged immunoglobulin (IG) or T-cell receptor (TR) genes is a valuable method in the diagnosis of suspect lymphoproliferative disorders. Additionally, this… read more here.
Keywords: immunoglobulin cell; rearranged immunoglobulin; receptor genes; analysis rearranged ... See more keywords
Isolation of Tailor-Made Antibody Fragments from Yeast-Displayed B-Cell Receptor Repertoires by Multiparameter Fluorescence-Activated Cell Sorting.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9853-1_14
Abstract: In the past decades, monoclonal antibodies have made an unprecedented transformation from research tools to a rapidly growing class of therapeutics. Advancements in the yeast surface display platform enable the selection of favorable mouse or… read more here.
Keywords: activated cell; antibody; selection; cell receptor ... See more keywords