Oxymatrine ameliorates diabetes‐induced aortic endothelial dysfunction via the regulation of eNOS and NOX4
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28006
Abstract: Oxymatrine (OMT) is the major quinolizidine alkaloid extracted from the root of Sophora flavescens Ait (the Chinese herb Kushen) and exhibits diverse pharmacological actions. In this study, we investigated the effects of OMT on diabetes‐associated… read more here.
Keywords: ameliorates diabetes; oxymatrine ameliorates; diabetes induced; endothelial dysfunction ... See more keywords
Protective effect of hypoglycemic granule against diabetes‐induced liver injury by alleviating glycolipid metabolic disorder and oxidative stress
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DOI: 10.1002/jcb.29588
Abstract: The current study was designed to explore the therapeutic effect and mechanism of different extraction, which came from hypoglycemic granule on diabetes‐induced liver injury. The ethanol fraction (HGEF) and aqueous fraction (HGAF) from hypoglycemic granule… read more here.
Keywords: hypoglycemic granule; liver injury; induced liver; granule diabetes ... See more keywords
Thioredoxin 1 overexpression attenuated diabetes‐induced endoplasmic reticulum stress in Müller cells via apoptosis signal‐regulating kinase 1
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30378
Abstract: As one of the common and serious chronic complications of diabetes mellitus (DM), the related mechanism of diabetic retinopathy (DR) has not been fully understood. Müller cell reactive gliosis is one of the early pathophysiological… read more here.
Keywords: apoptosis signal; ller; overexpression; signal regulating ... See more keywords
Identification of histone malonylation in the human fetal brain and implications for diabetes‐induced neural tube defects
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1403
Abstract: Neural tube defects (NTDs) are severe congenital malformations. Diabetes during pregnancy is a risk factor for NTDs, but its mechanism remains elusive. Emerging evidence suggests that protein malonylation is involved in diabetes. Here, we report… read more here.
Keywords: malonylation; tube defects; neural tube; identification histone ... See more keywords
Crocin Improves Diabetes-Induced Oxidative Stress via Downregulating the Nox-4 in Myocardium of Diabetic Rats.
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DOI: 10.1007/978-3-030-73234-9_18
Abstract: BACKGROUND Oxidative stress has a crucial role in the pathophysiology of cardiac dysfunction in the diabetic milieu. Crocin is a natural compound that acts as an antioxidant which could potentially ameliorate oxidative damages in various… read more here.
Keywords: myocardium diabetic; diabetic rats; myocardium; diabetes induced ... See more keywords
Photobiomodulation increases cell viability via AKT activation in an in vitro model of diabetes induced by glucose neurotoxicity
Sign Up to like & getrecommendations! Published in 2019 at "Lasers in Medical Science"
DOI: 10.1007/s10103-019-02808-2
Abstract: Peripheral neuropathy (PN) is a serious complication of diabetes mellitus (DM) and is known to be resistant to conventional treatment. Photobiomodulation (PBM) is demonstrated to be effective in treating PN and in protecting nerve fiber… read more here.
Keywords: induced glucose; vitro model; viability; neurotoxicity ... See more keywords
Diabetes-induced abnormalities of mitochondrial function in rat brain cortex: the effect of n-3 fatty acid diet
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3061-6
Abstract: Diabetic encephalopathy, a proven complication of diabetes is associated with gradually developing end-organ damage in the CNS increasing the risk of stroke, cognitive dysfunction or Alzheimer’s disease. This study investigated the response of rat cortical… read more here.
Keywords: mitochondrial function; cortical mitochondria; rat; function ... See more keywords
Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "GeroScience"
DOI: 10.1007/s11357-022-00565-9
Abstract: Diabetes mellitus promotes accelerated cardiovascular aging and inflammation, which in turn facilitate the development of cardiomyopathy/heart failure. High glucose-induced oxidative/nitrative stress, activation of various pro-inflammatory, and cell death pathways are critical in the initiation and… read more here.
Keywords: activation; fibrosis; diabetes induced; stress ... See more keywords
Effect of luteoin in delaying cataract in STZ-induced diabetic rats
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DOI: 10.1007/s12272-015-0669-5
Abstract: Luteolin, a flavonoid rich in many plants, has shown various pharmacological effects including anti-inflammation, anti-oxidant, anti-tumor, cardioprotective and neuroprotective properties. At present, inflammation and oxidative stress have been recognized to be two important contributing factors… read more here.
Keywords: luteoin delaying; delaying cataract; diabetic rats; diabetes induced ... See more keywords
Role of aldose reductase in diabetes-induced retinal microglia activation.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.01.020
Abstract: Diabetes-induced hyperglycemia plays a key pathogenic role in degenerative retinal diseases. In diabetic hyperglycemia, aldose reductase (AR) is elevated and linked to the pathogenesis of diabetic retinopathy (DR) and cataract. Retinal microglia (RMG), the resident… read more here.
Keywords: aldose reductase; retinal microglia; role; activation ... See more keywords
Amelioration of thyroid dysfunction by magnesium in experimental diabetes may also prevent diabetes-induced renal impairment
Sign Up to like & getrecommendations! Published in 2019 at "Heliyon"
DOI: 10.1016/j.heliyon.2019.e01660
Abstract: Background Diabetes mellitus has been reported to cause thyroid dysfunction, which may also impair renal function. Magnesium has been reported to exert ameliorative effects in diabetes mellitus. This study investigated thyroid and renal functions in… read more here.
Keywords: thyroid dysfunction; may also; magnesium; diabetes induced ... See more keywords