Simple Visualization Method for the c.577del of Erythropoietin Variant: CRISPR/dCas9 based Single Nucleotide Polymorphism Diagnosis.
Sign Up to like & getrecommendations! Published in 2023 at "Drug testing and analysis"
DOI: 10.1002/dta.3438
Abstract: One of the single nucleotide polymorphisms (SNPs) in human erythropoietin (hEPO), the c.577del variant, can produces 26 amino acids longer than the wild-type hEPO, posing a risk of misinterpretation in routine doping analysis. To prevent… read more here.
Keywords: method 577del; visualization method; single nucleotide; erythropoietin ... See more keywords
Neurogenic and pericytic plasticity of conditionally immortalized cells derived from renal erythropoietin‐producing cells
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DOI: 10.1002/jcp.30677
Abstract: In adult mammals, the kidney is the main source of circulating erythropoietin (Epo), the master regulator of erythropoiesis. In vivo data in mice demonstrated multiple subtypes of interstitial renal Epo‐producing (REP) cells. To analyze the… read more here.
Keywords: cell; rep; rep cells; plasticity ... See more keywords
Increased Urinary Erythropoietin Excretion in Severe Sleep Apnea-Hipoapnea Syndrome: The Effect of CPAP.
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DOI: 10.1016/j.arbres.2017.10.013
Abstract: INTRODUCTION Tissue hypoxia stimulates the production of erythropoietin (EPO), the main effect of which is, in turn, to stimulate erythropoiesis. Sleep apnea-hypopnea syndrome (SAHS) is an entity characterized by repeated episodes of hypoxemia during sleep.… read more here.
Keywords: erythropoietin; increased urinary; excretion; effect ... See more keywords
The role of recombinant Human erythropoietin in neonatal anemia.
Sign Up to like & getrecommendations! Published in 2019 at "Hematology/oncology and stem cell therapy"
DOI: 10.1016/j.hemonc.2019.08.004
Abstract: AIM To estimate the blood level of Erythropoietin (EPO) in neonates with anemia of prematurity (APO) and in late hypo-regenerative anemia and to clarify role of EPO in correction of anemia and reducing the number… read more here.
Keywords: erythropoietin; anemia; compared group; group ... See more keywords
An Integrated Strategy Reveals Complex Glycosylation of Erythropoietin Using Mass Spectrometry.
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DOI: 10.1021/acs.jproteome.1c00221
Abstract: The characterization of therapeutic glycoproteins is challenging due to the structural heterogeneity of the therapeutic protein glycosylation. This study presents an in-depth analytical strategy for glycosylation of first-generation erythropoietin (epoetin beta), including a developed mass… read more here.
Keywords: erythropoietin; analysis; mass; glycosylation ... See more keywords
Using chemical chaperones to increase recombinant human erythropoietin secretion in CHO cell line
Sign Up to like & getrecommendations! Published in 2019 at "Preparative Biochemistry and Biotechnology"
DOI: 10.1080/10826068.2018.1479865
Abstract: Abstract In recombinant protein production, over-expressed genes induce unfolded protein response (UPR), overloaded protein aggregation in endoplasmic reticulum and its expansion. In this study, we have used 16 chemicals to improve erythropoietin production in engineered… read more here.
Keywords: erythropoietin; secretion; endoplasmic reticulum; expansion ... See more keywords
Neuroprotection and endocytosis: erythropoietin receptors in insect nervous systems
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DOI: 10.1111/jnc.13967
Abstract: Erythropoietin (Epo) plays a dual role as an erythropoiesis‐stimulating hormone and a locally produced cytoprotectant in various vertebrate tissues. Splice variants and engineered derivatives of Epo that mediate neuroprotection but do not stimulate erythropoiesis suggest… read more here.
Keywords: erythropoietin; endocytosis erythropoietin; neuroprotection endocytosis; epo ... See more keywords
Erythropoietin promotes abdominal aortic aneurysms in mice through angiogenesis and inflammatory infiltration
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DOI: 10.1126/scitranslmed.aaz4959
Abstract: Erythropoietin dose-dependently induces abdominal aortic aneurysm in mice via JAK2/STAT5 signaling, even without angiotensin II infusion. Erythropoietin and AAA Abdominal aortic aneurysm (AAA) is a common vascular disease, but its pathogenesis has not been fully… read more here.
Keywords: erythropoietin; formation; epo; mice ... See more keywords
Recombinant Human Erythropoietin Proteins Synthesized in Escherichia coli Cells: Effects of Additional Domains on the in vitro and in vivo Activities
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DOI: 10.1134/s0006297919010036
Abstract: The aim of this work was to compare biological activities of three variants of bacterially expressed human recombinant erythropoietin (EPO) with additional protein domains: 6His-s-tag-EPO protein carrying the s-tag (15-a.a. oligopeptide from bovine pancreatic ribonuclease… read more here.
Keywords: hbd; erythropoietin; recombinant human; epo ... See more keywords
GP44 Erythropoietin as a treatment modality in hyperhaemolysis complicating sickle cell anaemia
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DOI: 10.1136/archdischild-2019-epa.110
Abstract: Introduction Hyperhaemolysis Syndrome (HS), a severe haemolytic transfusion reaction, is a rare complication in children with Sickle Cells anaemia (SCA) who require transfusion. Donor and autologous red cells are obliterated leading to a worsening of… read more here.
Keywords: erythropoietin; aged years; treatment; transfusion ... See more keywords
Cholinergic and cytoprotective signaling cascades mediate the mitigative effect of erythropoietin on acute radiation syndrome.
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DOI: 10.1139/cjpp-2017-0578
Abstract: The present investigation aimed to evaluate the radiomitigative efficacy of the recombinant human erythropoietin (EPO) against acute radiation syndrome (ARS) in a rat model. Rats were irradiated with a single sublethal dose of γ-radiation (7… read more here.
Keywords: acute radiation; erythropoietin; radiation syndrome; radiation ... See more keywords